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KMID : 0363020050350020491
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Journal of Korean Academy of Periodontology
2005 Volume.35 No. 2 p.491 ~ p.510
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Effect of inorganic polyphosphate on guided bone regeneration
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정종혁
권영혁/박준봉/허익
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Abstract
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This study was performed to evaluate the effect of inorganic polyphosphate on bone
formation in the calvaria of rabbit in the procedure of guided bone regeneration with bovine
cancellous bone graft and titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE)
membrane. The rabbits were divided into four groups. Control group I used only TR-ePTFE
membrane, control group II used TR-ePTFE membrane and deproteinized bovine bone
mineral soaked in saline, experimental group III and IV used TR-ePTFE membrane and
deproteinized bovine bone mineral soaked in 1% or 2% inorganic polyphosphate respectively.
After decortication in the calvaria, GBR procedure was performed on 12 rabbits with
titanium reinforced ePTFE membrane filled with deproteinized bovine bone mineral soaked in
saline or inorganic polyphosphate. The animals were sacrificed at 2 weeks, 4 weeks, and 8
weeks after the surgery. Decalcified and non-decalcified specimens were processed for
histologic and immunohistochemistric analysis.
1. Titanium reinforced ePTFE(TR-ePTFE) membrane showed good spacemaking and cell
occlusiveness capability, but it showed poor wound stabilization.
2. The deproteinized bovine bone mineral did not promote bone regeneration, but it acted
as a space filler.
3. There was no complete resorption of the deproteinized bovine bone mineral within 8
weeks.
4. 1% inorganic polyphosphate did not promote bone formation, but 2% inorganic polyphosphate promoted bone formation.
Within the above results, 2% inorganic polyphosphate could be used effectively for bone
regeneration.
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KEYWORD
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Inorganic polyphosphate, GBR, guided bone regeneration, TR-ePTFE
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